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Article

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

27 Dec 2012

Abstract excerpt

The striking differences between the clinical symptoms of tetanus and botulism have been ascribed to the different fate of the parental neurotoxins once internalised in motor neurons. Tetanus toxin (TeNT) is known to undergo transcytosis into inhibitory interneurons and block the release of inhibitory neurotransmitters in the spinal cord, causing a spastic paralysis. In contrast, botulinum neurotoxins (BoNTs)...

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PMID: 23300443
DOI: 10.1371/journal.ppat.1003087

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