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Article

Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin.

Biochemistry - 12 Apr 2011

Wang Dongsheng, Zhang Zhen, Dong Min, Sun Shihu, Chapman Edwin R, Jackson Meyer B

Abstract excerpt

Botulinum neurotoxins cleave synaptic SNAREs and block exocytosis, demonstrating that these proteins function in neurosecretion. However, the function of the SNARE syntaxin remains less clear because no neurotoxin cleaves it selectively. Starting with a botulinum neurotoxin that cleaves both syntaxin and SNAP-25, we engineered a version that retains activity against syntaxin but spares SNAP-25. These mutants...

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Identifiers

PMID: 21401123
DOI: 10.1021/bi200290p
PMCID: PMC3072107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin.PMID 21401123Read ↗

Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.Semantic proximity Read ↗

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.Semantic proximity Read ↗

Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.Semantic proximity Read ↗

Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.Semantic proximity Read ↗

Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability.Semantic proximity Read ↗

SNARE complex formation is triggered by Ca2+ and drives membrane fusion.Semantic proximity Read ↗

Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.Semantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

A discontinuous SNAP-25 C-terminal coil supports exocytosis.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteinsSemantic proximity Read ↗

Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.Semantic proximity Read ↗

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