Article
Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA.
Retrovirology - 13 Feb 2013
Shao Wei, Boltz Valerie F, Spindler Jonathan E, Kearney Mary F, Maldarelli Frank, Mellors John W, Stewart Claudia, Volfovsky Natalia, Levitsky Alexander, Stephens Robert M, Coffin John M
Abstract excerpt
BACKGROUND: 454 sequencing technology is a promising approach for characterizing HIV-1 populations and for identifying low frequency mutations. The utility of 454 technology for determining allele frequencies and linkage associations in HIV infected individuals has not been extensively investigat...
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