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Article

Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.

PloS one - 7 Jul 2010

Hedskog Charlotte, Mild Mattias, Jernberg Johanna, Sherwood Ellen, Bratt Göran, Leitner Thomas, Lundeberg Joakim, Andersson Björn, Albert Jan

Abstract excerpt

BACKGROUND: Ultra-deep pyrosequencing (UDPS) allows identification of rare HIV-1 variants and minority drug resistance mutations, which are not detectable by standard sequencing. PRINCIPAL FINDINGS: Here, UDPS was used to analyze the dynamics of HIV-1 genetic variation in reverse transcriptase (RT) (amino acids 180-220) in six individuals consecutively sampled before, during and after failing 3TC and AZT...

Topics

Anti-HIV Agents
Drug Resistance, Viral
HIV Infections
HIV-1
Humans
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20628644
DOI: 10.1371/journal.pone.0011345
PMCID: PMC2898805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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