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Article

Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies.

Nucleic acids research - 1 Nov 2010

Zagordi Osvaldo, Klein Rolf, Däumer Martin, Beerenwinkel Niko

Abstract excerpt

Next-generation sequencing technologies can be used to analyse genetically heterogeneous samples at unprecedented detail. The high coverage achievable with these methods enables the detection of many low-frequency variants. However, sequencing errors complicate the analysis of mixed populations and result in inflated estimates of genetic diversity. We developed a probabilistic Bayesian approach to minimize the...

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Identifiers

PMID: 20671025
DOI: 10.1093/nar/gkq655
PMCID: PMC2995073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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