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Article

MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Hutcheson Rebecca, Terry Russell, Chaplin Jennifer, Smith Erika, Musiyenko Alla, Russell James C, Lincoln Thomas, Rocic Petra

Abstract excerpt

OBJECTIVE: Transient, repetitive occlusion stimulates coronary collateral growth (CCG) in normal animals. Vascular smooth muscle cells (VSMCs) switch to synthetic phenotype early in CCG, then return to contractile phenotype. CCG is impaired in the metabolic syndrome. We determined whether impaired CCG was attributable to aberrant VSMC phenotypic modulation by miR-145-mediated mechanisms, and whether restoration...

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Source

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Identifiers

PMID: 23393394
DOI: 10.1161/ATVBAHA.112.301116
PMCID: PMC3628919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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