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Article

MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.

Circulation research - 17 Jul 2009

Cheng Yunhui, Liu Xiaojun, Yang Jian, Lin Ying, Xu Da-Zhong, Lu Qi, Deitch Edwin A, Huo Yuqing, Delphin Ellise S, Zhang Chunxiang

Abstract excerpt

Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA) miR-145 is the most abundant miRNA in normal vascular walls and in freshly isolated VSMCs; however, the role of miR-145 in VSMC phenotypic modulation and vascular diseases is currently unknown. Here we find that...

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Source

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Identifiers

PMID: 19542014
DOI: 10.1161/CIRCRESAHA.109.197517
PMCID: PMC2728297

Genes

KLF5

Provenance

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