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Article

Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function.

Journal of molecular and cellular cardiology - 1 Sept 2014

Riches Kirsten, Alshanwani Aliah R, Warburton Philip, O'Regan David J, Ball Stephen G, Wood Ian C, Turner Neil A, Porter Karen E

Abstract excerpt

Type 2 diabetes (T2DM) promotes premature atherosclerosis and inferior prognosis after arterial reconstruction. Vascular smooth muscle cells (SMC) respond to patho/physiological stimuli, switching between quiescent contractile and activated synthetic phenotypes under the control of microRNAs (miRs) that regulate multiple genes critical to SMC plasticity. The importance of miRs to SMC function specifically in T2DM...

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Identifiers

PMID: 24927876
DOI: 10.1016/j.yjmcc.2014.05.018
PMCID: PMC4121534

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