Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension.

Life sciences - 15 Apr 2018

Liao Jingwen, Zhang Yanyan, Wu Ying, Zeng Fanxing, Shi Lijun

Abstract excerpt

AIMS: This study investigated whether long-term exercise can influence vascular smooth muscle cells (VSMCs) phenotypic switching in mesenteric arteries of hypertensive rats, with a focus on the modulation of protein kinase B (PKB/Akt) signaling by microRNA-145 (miR-145). MAIN METHODS: In the exercise intervention experiment, mesenteric arteries from 3-month-old spontaneously hypertensive rats (SHR) and Wistar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypertension
Share to MicroRNAs
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Physical Conditioning, Animal

Share to Proto-Oncogene Proteins c-akt

Share to Rats, Inbred SHR

Share to Rats, Inbred WKY

Source

Identifiers

PMID: 29522767
DOI: 10.1016/j.lfs.2018.03.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension.PMID 29522767Read ↗

Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145.Semantic proximity Read ↗

Akt/eNOS and MAPK signaling pathways mediated the phenotypic switching of thoracic aorta vascular smooth muscle cells in aging/hypertensive rats.Semantic proximity Read ↗

Mechanical stretch suppresses microRNA-145 expression by activating extracellular signal-regulated kinase 1/2 and upregulating angiotensin-converting enzyme to alter vascular smooth muscle cell phenotype.Semantic proximity Read ↗

MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.Semantic proximity Read ↗

miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function.Semantic proximity Read ↗

IL-17 Promotes the Phenotypic Transformation of Vascular Smooth Muscle Cells Through PI3K/AKT Signaling Pathway.Semantic proximity Read ↗

Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and ObesitySemantic proximity Read ↗

Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling.Semantic proximity Read ↗

miR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection.Semantic proximity Read ↗

Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways.Semantic proximity Read ↗

MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.