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Article

miR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection.

Journal of clinical laboratory analysis - 1 Dec 2021

Qiu Zhi-Huang, He Jian, Chai Tian-Ci, Zhang Yu-Ling, Zhou Hao, Zheng Hui, Chen Xiao-Song, Zhang Li, Li Yu-Mei, Chen Liang-Wan

Abstract excerpt

BACKGROUND: miR-145 is closely related to vascular smooth muscle cells (VSMC) phenotype transformation; however, the regulatory mechanisms through which miR-145 regulates the VSMC phenotype transformation under mechanical stretching are unclear. In this study, we evaluated the roles of miR-145 in VSMCs subjected to mechanical stretching in aortic dissection (AD). METHODS: The expression of miR-145 in the aortic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34767671
DOI: 10.1002/jcla.23773
PMCID: PMC8649326

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