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Article

Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype.

The Journal of thoracic and cardiovascular surgery - 1 Aug 2014

Ohnaka Motoaki, Marui Akira, Yamahara Kenichi, Minakata Kenji, Yamazaki Kazuhiro, Kumagai Motoyuki, Masumoto Hidetoshi, Tanaka Shiro, Ikeda Tadashi, Sakata Ryuzo

Abstract excerpt

OBJECTIVE: Because microRNA-145 (miR-145) is a specific mediator in the regulation of the proliferation and differentiation of smooth muscle cells, we investigated the effect of miR-145 on the intimal hyperplasia in the rabbit model of vein graft disease using electroporation-mediated gene transfer. METHODS: The right jugular vein of male Japanese white rabbits was harvested and transduced with miR-145-encoding...

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Share to Carotid Artery, Common
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Neointima

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Source

Identifiers

PMID: 24507892
DOI: 10.1016/j.jtcvs.2013.11.054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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