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Article

Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145.

Journal of cellular and molecular medicine - 1 Jun 2016

Zhang Yu-Nan, Xie Bao-Dong, Sun Lu, Chen Wei, Jiang Shu-Lin, Liu Wei, Bian Fei, Tian Hai, Li Ren-Ke

Abstract excerpt

Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to an adverse proliferative phenotype is a hallmark of atherosclerosis or vascular restenosis. However, the genetic modulators responsible for this switch have not been fully elucidated in humans nor have they been correlated with clinical abnormalities. This study investigated genetic mechanisms involved in phenotypic switching of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26992033
DOI: 10.1111/jcmm.12825
PMCID: PMC4882986

Genes

KLF5
MYOCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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