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Article

Nucleophosmin: A versatile molecule associated with hematological malignancies

27 Jul 2006

Abstract excerpt

Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. In hematological malignancies, the NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. The NPM1 gene on 5q35 is translocated with the anaplastic lymphoma kinase (ALK) gene in anaplastic large...

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PMID: 16984370
DOI: 10.1111/j.1349-7006.2006.00270.x

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