Article
NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.
PLoS genetics - 1 Nov 2019
Darracq Anaïs, Pak Helen, Bourgoin Vincent, Zmiri Farah, Dellaire Graham, Affar El Bachir, Milot Eric
Abstract excerpt
Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-MLF1 translocation product favors the partial cytoplasmic retention of NPM....
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