Article
Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3.
Journal of experimental & clinical cancer research : CR - 6 Oct 2021
Jing Yipei, Jiang Xueke, Lei Li, Peng Meixi, Ren Jun, Xiao Qiaoling, Tao Yao, Tao Yonghong, Huang Junpeng, Wang Lu, Tang Yuting, Yang Zailin, Yang Zesong, Zhang Ling
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1), which displays a distinct long noncoding RNA (lncRNA) expression profile, has been defined as a unique subgroup in the new classification of myeloid neoplasms. However, the biological roles of key lncRNAs in the development of NPM1-mutated AML are currently unclear. Here, we aimed to investigate the functional and mechanistic roles of the...
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