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Nucleophosmin in Its Interaction with Ligands

10 Jul 2020

Abstract excerpt

Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli, nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic acids and proteins and plays a role in cell cycle control, centrosome duplication, ribosome maturation and export, as well as the cellular response to a variety of stress stimuli. NPM1 is a hub protein in nucleoli where it contributes to...

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PMID: 32664415
DOI: 10.3390/ijms21144885

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