Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.

The Journal of biological chemistry - 22 Mar 2013

Xie Jian, Yoon Joonho, Yang Sung-Sen, Lin Shih-Hua, Huang Chou-Long

Abstract excerpt

WNK1 is a widely expressed serine/threonine protein kinase that regulates multiple cellular and organ functions via diverse mechanisms. We previously reported that endothelial-specific deletion of Wnk1 in mice results in embryonic lethality, with angiogenesis and cardiac defects beginning at embryonic day ∼10.5. Here, we further investigated the signaling mechanism by which WNK1 regulates embryonic cardiovascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Abnormalities
Share to Cardiovascular System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Minor Histocompatibility Antigens

Share to Neovascularization, Physiologic

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to WNK Lysine-Deficient Protein Kinase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23386621
DOI: 10.1074/jbc.M113.451575
PMCID: PMC3605675

Genes

WNK1
OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.PMID 23386621Read ↗

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.Semantic proximity Read ↗

Essential role of endothelial Notch1 in angiogenesis.Semantic proximity Read ↗

Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium developmentSemantic proximity Read ↗

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.Semantic proximity Read ↗

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.Semantic proximity Read ↗

<i>Crk/Crkl</i> regulates early angiogenesis in mouse embryos by accelerating endothelial cell maturationSemantic proximity Read ↗

Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish.Semantic proximity Read ↗

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcriptionSemantic proximity Read ↗

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.Semantic proximity Read ↗

Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations.Semantic proximity Read ↗

meis1 regulates the development of endothelial cells in zebrafish.Semantic proximity Read ↗

Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.