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Article

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.

eLife - 22 Sept 2014

Gelfand Maria V, Hagan Nellwyn, Tata Aleksandra, Oh Won-Jong, Lacoste Baptiste, Kang Kyu-Tae, Kopycinska Justyna, Bischoff Joyce, Wang Jia-Huai, Gu Chenghua

Abstract excerpt

During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for vascular disease and cancer. NRP1 is essential for vascular morphogenesis, but how NRP1 functions...

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Identifiers

PMID: 25244320
DOI: 10.7554/eLife.03720
PMCID: PMC4197402

Genes

NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.PMID 25244320Read ↗

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