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Article

Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish.

Molecular genetics & genomic medicine - 1 Mar 2020

Nakagama Yu, Takeda Norihiko, Ogawa Seishi, Takeda Hiroyuki, Furutani Yoshiyuki, Nakanishi Toshio, Sato Tatsuyuki, Hirata Yoichiro, Oka Akira, Inuzuka Ryo

Abstract excerpt

BACKGROUND: Variants in the LZTR1 (leucine-zipper-like transcription regulator 1) gene (OMIM #600574) have been reported in recessive Noonan syndrome patients. In vivo evidence from animal models to support its causative role is lacking. METHODS: By CRISPR-Cas9 genome editing, we generated lztr1-mutated zebrafish (Danio rerio). Analyses of histopathology and downstream signaling were performed to investigate the...

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Identifiers

PMID: 31883238
DOI: 10.1002/mgg3.1107
PMCID: PMC7057116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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