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Article

Essential role of endothelial Notch1 in angiogenesis.

Circulation - 12 Apr 2005

Limbourg Florian P, Takeshita Kyosuke, Radtke Freddy, Bronson Roderick T, Chin Michael T, Liao James K

Abstract excerpt

BACKGROUND: Notch signaling influences binary cell fate decisions in a variety of tissues. The Notch1 receptor is widely expressed during embryogenesis and is essential for embryonic development. Loss of global Notch1 function results in early embryonic lethality, but the cell type responsible for this defect is not known. Here, we identify the endothelium as the primary target tissue affected by Notch1...

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Identifiers

PMID: 15809373
DOI: 10.1161/01.CIR.0000160870.93058.DD
PMCID: PMC2633594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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