Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations.

Circulation research - 15 Aug 2008

Venkatesh Deepak A, Park Kyung-Sook, Harrington Anne, Miceli-Libby Laura, Yoon Jeong K, Liaw Lucy

Abstract excerpt

Notch signaling is critical for the development and maintenance of the cardiovasculature, with loss-of-function studies defining roles of Notch1 in the endothelial/hematopoietic lineages. No in vivo studies have addressed complementary gain-of-function strategies within these tissues to define consequences of Notch activation. We developed a transgenic model of Cre recombinase-mediated activation of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular System
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Hematopoietic System

Share to Models, Animal

Share to Receptor, Notch1

Share to Receptor, TIE-2

Share to Yolk Sac

Source

Open in PubMed Open full text

Identifiers

PMID: 18617694
DOI: 10.1161/CIRCRESAHA.108.177808
PMCID: PMC2654335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations.PMID 18617694Read ↗

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow nicheSemantic proximity Read ↗

Essential role of endothelial Notch1 in angiogenesis.Semantic proximity Read ↗

Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.Semantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingSemantic proximity Read ↗

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.Semantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling.Semantic proximity Read ↗

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.Semantic proximity Read ↗

Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice.Semantic proximity Read ↗

Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells.Semantic proximity Read ↗

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle developmentSemantic proximity Read ↗

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.Semantic proximity Read ↗

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.