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Article

Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish.

Development (Cambridge, England) - 15 May 2024

Morooka Nanami, Gui Ning, Ando Koji, Sako Keisuke, Fukumoto Moe, Hasegawa Urara, Hußmann Melina, Schulte-Merker Stefan, Mochizuki Naoki, Nakajima Hiroyuki

Abstract excerpt

Development of the vascular system is regulated by multiple signaling pathways mediated by receptor tyrosine kinases. Among them, angiopoietin (Ang)/Tie signaling regulates lymphatic and blood vessel development in mammals. Of the two Tie receptors, Tie2 is well known as a key mediator of Ang/Tie signaling, but, unexpectedly, recent studies have revealed that the Tie2 locus has been lost in many vertebrate...

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Identifiers

PMID: 38742432
DOI: 10.1242/dev.202269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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