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Article

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

The American journal of pathology - 1 Sept 2009

Xie Jian, Wu Tao, Xu Ke, Huang Ivan K, Cleaver Ondine, Huang Chou-Long

Abstract excerpt

WNK1 [with-no-lysine (K)-1] is a ubiquitous serine/threonine kinase with a unique placement of the catalytic lysine residue. Increased WNK1 expression levels in humans causes a hypertension-hyperkalemia syndrome by altering renal Na(+) and K(+) transport. The function of WNK1 outside of the kidney remains elusive. In this study, we report that Wnk1 ablation causes cardiovascular developmental defects. The...

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Share to Endothelial Cells
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Minor Histocompatibility Antigens

Share to Neovascularization, Pathologic

Share to Protein Serine-Threonine Kinases

Share to Receptors, Notch

Share to WNK Lysine-Deficient Protein Kinase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 19644017
DOI: 10.2353/ajpath.2009.090094
PMCID: PMC2731149

Genes

WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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