Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

doi:10.1242/dev.126.20.4569

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Article

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

Development (Cambridge, England) - 1 Oct 1999

Puri M C, Partanen J, Rossant J, Bernstein A

Abstract excerpt

TEK (TIE2) and TIE (TIE1) are structurally related receptor tyrosine kinases expressed in endothelial cells and their precursors. Genetic studies in the mouse have revealed essential functions of both receptors in angiogenic expansion of the vasculature during development. As previously shown, mouse embryos homozygous for a disrupted Tek allele die by day 10.5 of embryogenesis due to endocardial defects,...

Topics

Animals
Base Sequence
Cardiovascular System
Chimera
DNA Primers
Female
Gene Expression Regulation, Developmental
Homozygote
Male
Mice
Mice, Knockout
Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mosaicism

Phenotype

Pregnancy

Receptor Protein-Tyrosine Kinases

Receptor, TIE-1

Source

Open in PubMed

Identifiers

PMID: 10498691
DOI: 10.1242/dev.126.20.4569

Genes

TEK
TIE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.PMID 10498691Read ↗

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