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Article

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

Development (Cambridge, England) - 1 Oct 1999

Puri M C, Partanen J, Rossant J, Bernstein A

Abstract excerpt

TEK (TIE2) and TIE (TIE1) are structurally related receptor tyrosine kinases expressed in endothelial cells and their precursors. Genetic studies in the mouse have revealed essential functions of both receptors in angiogenic expansion of the vasculature during development. As previously shown, mouse embryos homozygous for a disrupted Tek allele die by day 10.5 of embryogenesis due to endocardial defects,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

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Share to Receptor Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 10498691
DOI: 10.1242/dev.126.20.4569

Genes

TEK
TIE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.PMID 10498691Read ↗

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.Semantic proximity Read ↗

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.Semantic proximity Read ↗

Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish.Semantic proximity Read ↗

Angiopoietin-1 is essential in mouse vasculature during development and in response to injurySemantic proximity Read ↗

Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations.Semantic proximity Read ↗

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.Semantic proximity Read ↗

Tie1 regulates zebrafish cardiac morphogenesis through Tolloid-like 1 expression.Semantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingSemantic proximity Read ↗

Genetic Dissection of Tie Pathway in Mouse Lymphatic Maturation and Valve DevelopmentSemantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling.Semantic proximity Read ↗

Angiopoietin 1 expression levels in the myocardium direct coronary vessel development.Semantic proximity Read ↗

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.Semantic proximity Read ↗

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