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Article

Genetically determined severity of anti-myeloperoxidase glomerulonephritis.

The American journal of pathology - 1 Apr 2013

Xiao Hong, Ciavatta Dominic, Aylor David L, Hu Peiqi, de Villena Fernando Pardo-Manuel, Falk Ronald J, Jennette J Charles

Abstract excerpt

Myeloperoxidase (MPO) is a target antigen for antineutrophil cytoplasmic autoantibodies (ANCA). There is evidence that MPO-ANCA cause necrotizing and crescentic glomerulonephritis (NCGN) and vasculitis. NCGN severity varies among patients with ANCA disease, and genetic factors influence disease severity. The role of genetics in MPO-ANCA NCGN severity was investigated using 13 inbred mouse strains, F1 and F2...

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Share to Antibodies, Antineutrophil Cytoplasmic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23384999
DOI: 10.1016/j.ajpath.2012.12.006
PMCID: PMC3620395

Genes

MPO
CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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