Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis.

Abstract excerpt

Background: Both intrinsic renal cells and immune cells contribute to driving renal inflammation and damage. However, the respective roles of intrinsic renal cells and immune cells in crescentic glomerulonephritis, and the key molecular factors driving pathogenesis are still unclear. Methods: The roles of intrinsic renal cells and renal infiltrating immune cells in crescent formation were explored using renal...

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