Article
Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006
Hamano Yoshitomo, Tsukamoto Kazuyuki, Abe Masaaki, Sun Guo Dong, Zhang Danqing, Fujii Hiroaki, Matsuoka Shuji, Tanaka Masumi, Ishida-Okawara Akiko, Tachikawa Hitoshi, Nishimura Hiroyuki, Tokunaka Kazuhiro, Hirose Sachiko, Suzuki Kazuo
Abstract excerpt
The spontaneous crescentic glomerulonephritis-forming/Kinjoh (SCG/Kj) mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA). Although the disease is mediated initially by mutation of the Fas gene (lpr), SCG/Kj mice also have non-Fas predisposing genetic factors. To define these...
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