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Article

Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis.

Journal of the American Society of Nephrology : JASN - 1 Jul 2010

Behmoaras Jacques, Smith Jennifer, D'Souza Zelpha, Bhangal Gurjeet, Chawanasuntoropoj Ratana, Tam Frederick W K, Pusey Charles D, Aitman Timothy J, Cook H Terence

Abstract excerpt

The Wistar Kyoto (WKY) rat is uniquely susceptible to experimentally induced crescentic glomerulonephritis. Two major quantitative trait loci (QTLs) on chromosomes 13 (Crgn1) and 16 (Crgn2) with logarithm of odds >8, as well as five other loci (Crgn3 through 7), largely explain this genetic susceptibility. To understand further the effects of Crgn1 and Crgn2, we generated a double-congenic strain by introgressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20488952
DOI: 10.1681/ASN.2009090968
PMCID: PMC3152224

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