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Article

The Gne M712T mouse as a model for human glomerulopathy.

The American journal of pathology - 1 Apr 2012

Kakani Sravan, Yardeni Tal, Poling Justin, Ciccone Carla, Niethamer Terren, Klootwijk Enriko D, Manoli Irini, Darvish Daniel, Hoogstraten-Miller Shelley, Zerfas Patricia, Tian E, Ten Hagen Kelly G, Kopp Jeffrey B, Gahl William A, Huizing Marjan

Abstract excerpt

Pathological glomerular hyposialylation has been implicated in certain unexplained glomerulopathies, including minimal change nephrosis, membranous glomerulonephritis, and IgA nephropathy. We studied our previously established mouse model carrying a homozygous mutation in the key enzyme of sialic acid biosynthesis, N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Mutant mice died before postnatal day 3...

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Identifiers

PMID: 22322304
DOI: 10.1016/j.ajpath.2011.12.023
PMCID: PMC3349896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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