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Article

Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.

Clinical and experimental immunology - 1 Aug 2007

Rajp A, Adu D, Savage C O

Abstract excerpt

Wegener's granulomatosis, microscopic polyangiitis and Churg Strauss syndrome are small-vessel vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) and myeloperoxidase (MPO). A G to A polymorphism at position 463 in the promoter region of the MPO gene, which leads to the loss of a SP1 transcription binding site in an Alu hormone responsive element, reduces...

Topics

Antibodies, Antineutrophil Cytoplasmic
Autoimmune Diseases
Creatinine
Disease Progression
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Humans
Male
Neutrophils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxidase

Polymerase Chain Reaction

Polymorphism, Genetic

Survival Analysis

Vasculitis

Source

Open in PubMed Open full text

Identifiers

PMID: 17521322
DOI: 10.1111/j.1365-2249.2007.03418.x
PMCID: PMC1941960

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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