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Article

Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus.

The Journal of rheumatology - 1 Oct 2007

Bouali Henda, Nietert Paul, Nowling Tamara M, Pandey Janardan, Dooley Mary Anne, Cooper Glinda, Harley John, Kamen Diane L, Oates Jim, Gilkeson Gary

Abstract excerpt

OBJECTIVE: Myeloperoxidase (MPO) is an enzyme expressed in neutrophils that is involved in tissue damage in inflammatory renal diseases. A functional G to A single-nucleotide polymorphism (SNP) is present at position -463 of the MPO promoter region and is associated with altered MPO expression. We hypothesized that the G-463A MPO SNP is a risk factor for developing lupus nephritis (LN) due to its potential...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 17896805
PMCID: PMC2798120

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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