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Article

Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis.

The Journal of experimental medicine - 21 Oct 2013

Ge Yan, Jiang Chao, Sung Sun-Sang J, Bagavant Harini, Dai Chao, Wang Hongyang, Kannapell Carol C, Cathro Helen P, Gaskin Felicia, Fu Shu Man

Abstract excerpt

Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) and acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J region where Cgnz1 is located to NZM2328. R27 female mice developed aGN mediated by immune complex (IC) deposition and complement activation without progression to cGN with severe proteinuria. End stage renal disease (ESRD)...

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Identifiers

PMID: 24101379
DOI: 10.1084/jem.20130731
PMCID: PMC3804943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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