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Article

Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication.

Nucleic acids research - 6 Jul 2018

Grimwade Julia E, Rozgaja Tania A, Gupta Rajat, Dyson Kyle, Rao Prassanna, Leonard Alan C

Abstract excerpt

In all cells, initiation of chromosome replication depends on the activity of AAA+ initiator proteins that form complexes with replication origin DNA. In bacteria, the conserved, adenosine triphosphate (ATP)-regulated initiator protein, DnaA, forms a complex with the origin, oriC, that mediates DNA strand separation and recruitment of replication machinery. Complex assembly and origin activation requires...

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Identifiers

PMID: 29800247
DOI: 10.1093/nar/gky457
PMCID: PMC6158602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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