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Article

Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication.

PLoS genetics - 1 Feb 2017

Schenk Katrin, Hervás Ana B, Rösch Thomas C, Eisemann Marc, Schmitt Bernhard A, Dahlke Stephan, Kleine-Borgmann Luise, Murray Seán M, Graumann Peter L

Abstract excerpt

DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity binding sites at the origin region and upon an unknown molecular trigger, spreads to several adjacent sites, inducing the formation of a helical super structure leading to initiation of replication. Using FRAP analysis of a...

Topics

Adenosine Triphosphatases
Bacillus subtilis
Bacterial Proteins
DNA Replication
DNA-Binding Proteins
Escherichia coli
Gene Expression Regulation, Bacterial
Mutation
Origin Recognition Complex
Replication Origin

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PMID: 28166228
DOI: 10.1371/journal.pgen.1006561
PMCID: PMC5319796

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