Article
Subsets of microsatellite-unstable colorectal cancers exhibit discordance between the CpG island methylator phenotype and MLH1 methylation status.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2013
Kim Jung H, Rhee Ye-Y, Bae Jeong-M, Kwon Hyeong-J, Cho Nam-Y, Kim Mi J, Kang Gyeong H
Abstract excerpt
Although the presence of MLH1 methylation in microsatellite-unstable colorectal cancer generally indicates involvement of the CpG island methylator phenotype (CIMP) in the development of the tumor, these two conditions do not always correlate. A minority of microsatellite-unstable colorectal cancers exhibit discordance between CIMP and MLH1 methylation statuses. However, the clinicopathological features of such...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.