Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.

doi:10.1158/1055-9965.EPI-15-0935

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Article

Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2016

Levine A Joan, Phipps Amanda I, Baron John A, Buchanan Daniel D, Ahnen Dennis J, Cohen Stacey A, Lindor Noralane M, Newcomb Polly A, Rosty Christophe, Haile Robert W, Laird Peter W, Weisenberger Daniel J

Abstract excerpt

BACKGROUND: The CpG island methylator phenotype (CIMP) is a major molecular pathway in colorectal cancer. Approximately 25% to 60% of CIMP tumors are microsatellite unstable (MSI-H) due to DNA hypermethylation of the MLH1 gene promoter. Our aim was to determine if the distributions of clinicopathologic factors in CIMP-positive tumors with MLH1 DNA methylation differed from those in CIMP-positive tumors without...

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Identifiers

PMID: 26512054
DOI: 10.1158/1055-9965.EPI-15-0935
PMCID: PMC4713308

Genes

MLH1
BRAF
KRAS
IMPACT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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