Article
Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway.
Oncotarget - 22 Mar 2016
Kim Jung Ho, Bae Jeong Mo, Cho Nam-Yun, Kang Gyeong Hoon
Abstract excerpt
The presence or absence of MLH1 methylation may critically affect the heterogeneity of colorectal carcinoma (CRC) with the CpG island methylator phenotype (CIMP). Here, we investigated the differential characteristics of CIMP-high (CIMP-H) CRCs according to MLH1 methylation status. To further con...
Topics
- Adenocarcinoma, Mucinous
- Adenoma
- Aged
- Biomarkers, Tumor
- Carcinoma, Signet Ring Cell
- Colorectal Neoplasms
- Core Binding Factor Alpha 3 Subunit
- CpG Islands
- DNA Methylation
- Female
- Follow-Up Studies
- Humans
- Lymphatic Metastasis
- Male
- Microsatellite Instability
- MutL Protein Homolog 1
- Mutation
- Neoplasm Grading