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Article

Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.

Genes, chromosomes & cancer - 1 Oct 2008

Alemayehu Aster, Sebova Katarina, Fridrichova Ivana

Abstract excerpt

Lynch syndrome is an inherited disease resulting predominantly in colorectal cancer (CRC). The crucial cause is DNA mismatch repair (MMR) malfunction that is associated mostly with MLH1 or MSH2 germline mutations. A significant hallmark of repair defects is a high level of instability in microsatellites (MSI-H). In many sporadic unstable CRCs, the MLH1 gene is inactivated by promoter hypermethylation in addition...

Read the complete abstract on PubMed

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Share to Adaptor Proteins, Signal Transducing
Share to Colon
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 18618713
DOI: 10.1002/gcc.20586

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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