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Article

The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Mar 2005

Velayos Fernando S, Lee Suk-Hwan, Qiu Hongming, Dykes Sharon, Yiu Raymond, Terdiman Jonathan P, Garcia-Aguilar Julio

Abstract excerpt

MLH1 promoter hypermethylation has been described as the primary mechanism for high-frequency microsatellite instability (MSI-H) in sporadic colorectal cancers (CRCs). The underlying molecular mechanism for microsatellite instability (MSI) in synchronous and metachronous CRCs is not well described. A total of 33 metachronous CRC patients and 77 synchronous CRC patients were identified from 2884 consecutive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15749592
DOI: 10.1016/j.gassur.2004.05.007

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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