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Article

Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.

Cancer research - 1 Oct 2007

Hitchins Megan P, Lin Vita Ap, Buckle Andrew, Cheong Kayfong, Halani Nimita, Ku Su, Kwok Chau-To, Packham Deborah, Suter Catherine M, Meagher Alan, Stirzaker Clare, Clark Susan, Hawkins Nicholas J, Ward Robyn L

Abstract excerpt

Biallelic promoter methylation and transcriptional silencing of the MLH1 gene occurs in the majority of sporadic colorectal cancers exhibiting microsatellite instability due to defective DNA mismatch repair. Long-range epigenetic silencing of contiguous genes has been found on chromosome 2q14 in colorectal cancer. We hypothesized that epigenetic silencing of MLH1 could occur on a regional scale affecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17909015
DOI: 10.1158/0008-5472.CAN-07-0869

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.PMID 17909015Read ↗

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