Article
MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.
The Journal of pathology - 1 Jan 2013
Donehower Lawrence A, Creighton Chad J, Schultz Nikolaus, Shinbrot Eve, Chang Kyle, Gunaratne Preethi H, Muzny Donna, Sander Chris, Hamilton Stanley R, Gibbs Richard A, Wheeler David
Abstract excerpt
Approximately 15% of colorectal carcinomas (CRCs) exhibit a hypermutated genotype accompanied by high levels of microsatellite instability (MSI-H) and defects in DNA mismatch repair. These tumours, unlike the majority of colorectal carcinomas, are often diploid, exhibit frequent epigenetic silencing of the MLH1 DNA mismatch repair gene, and have a better clinical prognosis. As an adjunct study to The Cancer...
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