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Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status

1 Jan 2014

Abstract excerpt

BACKGROUND: Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs. METHODS: Expression of EPCAM and DNA mismatch repair proteins was...

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Share to Colorectal Cancer Treatments and Studies
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PMID: 25214859
DOI: 10.4132/koreanjpathol.2014.48.4.276

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