Article
Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2023
Hou Guojun, Zhou Tian, Xu Ning, Yin Zhihua, Zhu Xinyi, Zhang Yutong, Cui Yange, Ma Jianyang, Tang Yuanjia, Cheng Zhaorui, Shen Yiwei, Chen Yashuo, Zou Ling-Hua, Wang Yong-Fei, Yin Zihang, Guo Ya, Ding Huihua, Ye Zhizhong, Shen Nan
Abstract excerpt
OBJECTIVE: IRF5 plays a crucial role in the development of lupus. Genome-wide association studies have identified several systemic lupus erythematosus (SLE) risk single-nucleotide polymorphisms (SNPs) enriched in the IRF5 locus. However, no comprehensive genome editing-based functional analysis exists to establish a direct link between these variants and altered IRF5 expression, particularly for enhancer...
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