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Article

Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2.

The Journal of biological chemistry - 8 Mar 2013

Theisen Joshua W M, Gucwa James S, Yusufzai Timur, Khuong Mai T, Kadonaga James T

Abstract excerpt

MeCP2 is an abundant methyl-cytosine-guanine (CG)-binding protein and transcriptional repressor. We developed a biochemical system that exhibits CG methylation-specific transcriptional repression by purified human MeCP2. MeCP2 represses transcription by histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Our system appears to recreate the HDAC-independent component of MeCP2-mediated repression...

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Identifiers

PMID: 23349465
DOI: 10.1074/jbc.M112.438697
PMCID: PMC3591619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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