Article

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

2025-02-05

Abstract excerpt

The detection of cytosolic dsDNA is tightly regulated to avoid pathological inflammatory responses. A major pathway involved in their detection relies on the cyclic GMP-AMP synthase (cGAS) that triggers activation of the Stimulator of interferon genes (STING) which subsequently drives the expression of inflammatory genes and type I Interferons (IFNs). Here, we show that the methyl-CpG-binding protein 2 (MECP2), a...

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Literature Corpus work: 8894e0aa-2809-50cd-85eb-61939b15628c
DOI: 10.1101/2025.01.30.635818

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