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Article

Early life adversity is associated with brain changes in subjects at family risk for depression.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Dec 2012

Carballedo Angela, Lisiecka Danutia, Fagan Andrew, Saleh Karim, Ferguson Yolande, Connolly Gerard, Meaney James, Frodl Thomas

Abstract excerpt

OBJECTIVE: The interplay of genetic and early environmental factors is recognized as an important factor in the aetiology of major depressive disorder (MDD). The aim of the present study was to examine whether reduced volume of hippocampus and frontal brain regions involved in emotional regulation are already present in unaffected healthy individuals at genetic risk of suffering MDD and to investigate whether...

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Identifiers

PMID: 22515408
DOI: 10.3109/15622975.2012.661079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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