Article
Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders.
Journal of psychiatric research - 1 Dec 2014
Aas Monica, Haukvik Unn K, Djurovic Srdjan, Tesli Martin, Athanasiu Lavinia, Bjella Thomas, Hansson Lars, Cattaneo Annamaria, Agartz Ingrid, Andreassen Ole A, Melle Ingrid
Abstract excerpt
OBJECTIVE: Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met). METHOD: A total of 323 patients with a broad DSM-IV schizophrenia spectrum disorder or bipolar disorder were...
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