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Article

Sex modulates the interactive effect of the serotonin transporter gene polymorphism and childhood adversity on hippocampal volume.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2012

Everaerd Daphne, Gerritsen Lotte, Rijpkema Mark, Frodl Thomas, van Oostrom Iris, Franke Barbara, Fernández Guillén, Tendolkar Indira

Abstract excerpt

The common genetic variation of the serotonin transporter-linked polymorphic region (5-HTTLPR) has been related to depressive symptoms, in particular after stressful life events. Although it has been investigated in the past, results suggesting that the 5-HTTLPR genotype also affects hippocampal volume are often inconsistent and it remains unclear to what extent reduced hippocampal volume is influenced by the...

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Identifiers

PMID: 22434222
DOI: 10.1038/npp.2012.32
PMCID: PMC3376317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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