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Article

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.

Human gene therapy - 1 Mar 2013

Apolloni Ann, Lin Min-Husan, Sivakumaran Haran, Li Dongsheng, Kershaw Michael H R, Harrich David

Abstract excerpt

Here we show potent inhibition of HIV-1 replication in a human T cell line and primary human CD4(+) cells by expressing a single antiviral protein. Nullbasic is a mutant form of the HIV-1 Tat protein that was previously shown to strongly inhibit HIV-1 replication in nonhematopoietic cell lines by targeting three steps of HIV-1 replication: reverse transcription, transport of viral mRNA, and trans-activation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia Virus, Murine

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Source

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Identifiers

PMID: 23298160
DOI: 10.1089/hum.2012.176
PMCID: PMC3696950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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