Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.

doi:10.1089/aid.1993.9.839

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Article

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.

AIDS research and human retroviruses - 1 Sept 1993

Arya S K

Abstract excerpt

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat) is an important trans-regulator of viral gene expression. It differs from the related HIV-1 Tat in certain aspects of its structure and function. HIV-2 Tat is composed of 130 amino acids versus 86 amino acids for HIV-1 Tat. Apart from certain conserved regions, there is little homology between the two Tats. They also differ in their ability to...

Topics

Amino Acid Sequence
Consensus Sequence
Gene Products, tat
HIV Long Terminal Repeat
HIV-1
HIV-2
HeLa Cells
Humans
Models, Molecular
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

RNA, Messenger

RNA, Viral

Sequence Alignment

Sequence Homology, Amino Acid

T-Lymphocytes

Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 8257633
DOI: 10.1089/aid.1993.9.839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8257633-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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